Historically, researchers focused on individuals with severe disabilities have utilized single-subject research methodologies to study the application of the behavioral theory to learning. In contrast, disability studies scholars have primarily used qualitative research methodologies to study quality of life or policy issues related to individuals with significant disabilities. Also, less emphasis has been placed on quantitative research using medium to large data sets, despite the impact this research can have on policy and practice. This article discusses possibilities for applying a disability studies theoretical framework to quantitative research in ways that can empower individuals with significant disabilities and introduces possibilities for broadening research by encouraging a dialogue among fields of inquiry. (Contains 1 table, 1 figure and 1 footnote.)