ERIC Number: EJ768118
Record Type: Journal
Publication Date: 2005-Sep
Pages: 5
Abstractor: Author
ISBN: N/A
ISSN: ISSN-1072-0502
EISSN: N/A
Protein Synthesis Underlies Post-Retrieval Memory Consolidation to a Restricted Degree Only when Updated Information Is Obtained
Rodriguez-Ortiz, Carlos J.; De la Cruz, Vanesa; Gutierrez, Ranier; Bermudez-Rattoni, Federico
Learning & Memory, v12 n5 p533-537 Sep 2005
Consolidation theory proposes that through the synthesis of new proteins recently acquired memories are strengthened over time into a stable long-term memory trace. However, evidence has accumulated suggesting that retrieved memory is susceptible to disruption, seeming to consolidate again (reconsolidate) to be retained in long-term storage. Here we show that intracortical blockade of protein synthesis in the gustatory cortex after retrieval of taste-recognition memory disrupts previously consolidated memory to a restricted degree only if the experience is updated. Our results suggest that retrieved memory can be modified as part of a mechanism for incorporating updated information into previously consolidated memory. (Contains 3 figures.)
Descriptors: Long Term Memory, Patterned Responses, Neuropsychology, Mnemonics, Sensory Experience, Perceptual Motor Coordination, Retention (Psychology), Recall (Psychology), Molecular Biology, Scientific Methodology, Scientific Research
Cold Spring Harbor Laboratory Press. 500 Sunnyside Boulevard, Woodbury, NY 11797-2924. Tel: 800-843-4388; 516-367-8800; Fax: 516-422-4097; e-mail: cshpres@cshl.edu; Web site: http://www.learnmem.org/
Publication Type: Journal Articles; Reports - Research
Education Level: N/A
Audience: N/A
Language: English
Sponsor: N/A
Authoring Institution: N/A
Grant or Contract Numbers: N/A