We describe our activities that emerged in the context of an Office of Distance Education and Learning Technologies' efforts to systematically and systemically address accessibility for online learning in order to comply with ethical principles, best practices, and laws. The activities include three overarching continuous tasks: strategically monitoring campus needs and resources, building a supportive infrastructure, and evaluating outcomes. Conscientious assessment of needs informs development of the collaborative support infrastructure necessary to establish a supportive campus culture with instructors and staff who use facilitative software to create accessible online opportunities for students. We provide a practical checklist for reviewing online instruction for accessibility.