This study examined the unique and interactive contributions of school connectedness, negative family relations, and effortful control to subsequent early adolescent conduct problems. Data were collected from 476 adolescents when they were initially in the 6th and 7th grades and again 1 year later. Results from hierarchical regression analyses showed that even after controlling for negative family relations, effortful control, baseline levels of conduct problems, and gender, school connectedness contributed to decreasing subsequent conduct problems. Examination of 2- and 3-way interactions indicated that high levels of school connectedness offset the adverse effects of negative family relations for boys and girls and the adverse effects of low levels of effortful control for girls. Findings underscore the role of school connectedness as a protective factor for early adolescent conduct problems. (Contains 2 tables.)