While technology has enabled online education in many countries, the same cannot be said for African public universities. Universities in Ghana have made some progress in building networking infrastructure and acquiring computers, but integrating technology into the teaching and learning process has been a challenge. Instructional delivery remains largely instructor-led, with limited or no electronic collaboration between students and lecturers. To meet their objective of increasing enrollment through distance education programs, universities must establish appropriate e-learning policies and get the implementation of e-learning systems right the first time, establishing a record of success to build upon. In this article, the author discusses the barriers for implementing e-learning systems in Ghana's public universities and suggests several strategies for successful implementation. The author states that introducing pedagogy-supporting technology in higher education in Ghana requires rethinking institutional policies and lining up stakeholder support. (Contains 5 endnotes.)