Based on data from qualitative interviews with 50 high-achieving low-socioeconomic students of color, two "clusters" of important and symbiotic protective factors are identified and explored. Each cluster consists of a series of interrelated protective factors identified by the participants as crucial to their statistically exceptional academic achievement. Using resilience theory, a detailed examination of how these groups of protective factors mitigated the potential effects of risk factors, thus contributing to the process of academic resilience, is presented. Practical uses of protective factor clusters also are presented and explored. (Contains 2 tables.)