Age-related macular degeneration (AMD) is a leading cause of vision loss in Americans aged 60 and older. The loss of central vision from AMD can decrease visual acuity, contrast sensitivity, glare sensitivity, color discrimination, and the ability to adapt to changes in lighting conditions. Older adults with vision loss often have other chronic, comorbid conditions that cause some level of difficulty with mobility tasks. This article explores, from the author's experience, key conditions that influence functional mobility and how these limitations affect the safety of older adults. The focus is not on the visual impairment, but on the chronic, comorbid conditions that affect the mobility of older adults. Since functional vision may change throughout the day and under different weather and environmental conditions, functional assessments should identify unsafe practices in all types of situations. Training should incorporate the recognition of factors that influence vision and the implementation of compensatory strategies to maximize safe travel.