Motor vehicle accidents (MVAs) are fairly common occurrences in all developed countries. Although only a small percentage of total MVAs result in posttraumatic stress disorder (PTSD), the high base rate in the population has resulted in the estimation that MVAs are the leading cause of PTSD in the United States. Occupations that require substantial travel, such as long-haul trucking, significantly increase the risk of being exposed to a traumatic MVA. Developing PTSD secondary to such exposure can be disabling and can thus have significant and specific implications for occupational functioning. This case study describes the successful treatment, using Cognitive Processing Therapy (CPT), of a long-haul trucker diagnosed with PTSD after a serious MVA. The intervention is described and the results discussed with specific attention both to this case as well as to its generalizability to the larger MVA trauma population. (Contains 3 tables and 1 figure.)