The aim of this study was to examine the consonant-vowel co-occurrence patterns predicted by the Frame-Content theory in 16 nine-month-old babies with unrepaired cleft palate ([plus or minus]cleft lip) and 16 age-matched non-cleft babies. Babble from these babies was phonetically transcribed and grouped according to the intrasyllabic predictions of the theory (labial-central, alveolar-front, and velar-back). Both groups demonstrated the three consonant-vowel co-occurrence patterns predicted by the Frame-Content theory. Other patterns not predicted by the Frame-Content theory emerged as strong patterns as well. Learning outcomes: The reader will be able to: [middle dot] Describe consonant-vowel co-occurrence patterns produced by babies with and without cleft palate. [middle dot] Describe vowel inventories of babies with cleft palate. [middle dot] Identify possible therapy targets for babies with cleft palate.