Background: This longitudinal study of 20 average and bright adults with parents with cognitive difficulties follows a study 20 years earlier of their childhood adaptation to their parents. Method: Semistructured interviews about life situation and changes and perception of family-of-origin. Results: The participants' socioeconomic status changed from poverty to a bell curve from upper middle class to underclass, with working class the mode. There was a high incidence of psychological disorders, especially depression and drug disorders, but two-fifths were currently diagnosis-free and one-fifth lifetime diagnosis-free. Three-fourths expressed a realistic view of their parents' difficulties. Nearly half the parents have received social support from their adult children, both those without and those with cognitive difficulties. Conclusion: Professionals should recognize the potential of children of parents with cognitive difficulties and their need for opportunity and family guidance on their behalf.