An increasing number of children experience chronic health issues that affect their academic and behavioral functioning, as well as psychological well-being. At the same time, psychological stress can exacerbate the chronic illness. The first line of treatment most often is medical (e.g., pharmacology, surgery, radiation). Even when the medical approach addresses the physical issues adequately, there may be residual effects on functioning. To better address overall well-being, as well as to potentially decrease reliance on medication, one approach has been to use mind-body or mindfulness interventions. Overall, results from existing studies suggest that mindfulness interventions may be beneficial for reducing symptoms and associated problems through relaxation for many chronic illnesses, including epilepsy, fibromyalgia, headaches or migraines, cancer, and asthma. While the research is promising, there is a need for additional, more controlled studies that integrate mind-body approaches with traditional medical approaches. Suggestions for future studies are provided.