Child abuse and neglect prevention is a complex field due, in part, to the diverse and numerous factors that can lead to maltreatment. As a result, prevention strategies, interventions, and initiatives must address multiple issues and rely on expertise from a variety of disciplines. This literature review considers recent and multidisciplinary research that can lead to innovative and improved ways to target, design, and monitor child abuse prevention efforts. The author identifies and explores eight promising trends or lines of learning. The paper discusses implications for future research, program planning and public policy relevant to preventing maltreatment, strengthening families, and promoting the health and well-being of children. Names and affiliations of experts interviewed in 2011 are appended. (Contains 12 footnotes.)