The present research examined the extent to which pre-college characteristics, high school experiences, college expectations, and initial enrollment characteristics were related to graduation from college. Data from admission applications, the "ACT Compass" survey, and initial enrollment measures for Fall 2004 and Fall 2005 first-time students were analyzed. Because almost one-third of the students had missing data, multiple imputation procedures were utilized. Results revealed that several measures of student characteristics, high school experiences, college expectations, and initial enrollment characteristics were consistently related to degree attainment. Other variables were related to a single degree-attainment measure. These results demonstrated that pre-matriculation data can be used to identify at-risk students, identify risk factors, and provide institution-specific benchmarks for evaluating efforts to improve degree attainment.