The current study deals with freshman students who study at the Department of Science at the Faculty of Education. The aim of the study was to investigate the effect of teaching electrochemistry concepts using Predict-Observe-Explain (POE) strategy. The study was quasi-experimental design using 20 students each in the experimental group (EG) and control group (CG). An Open-Ended Test (OET) and Multiple Choice Test (MCT) were used as pre- and post-test respectively. The POE was used to treat the experimental group, post test scores showed a statistically significant difference in performance by the EG, which had less misconception. The results of this study suggest that using The POE strategy is conceptual understanding.