This study evaluated the effectiveness of a community health promotion project to increase HIV knowledge in an urban, immigrant Latino community in Chicago. Latino participants (N = 704) answered questions on HIV before and after an education intervention given by community health workers. Outcomes included changes in knowledge and self-perceived risk. Increases in knowledge scores were greatest for Central/South Americans (p = .038), women (p = .027), and those with an education level less than 7 years (p = .001). Significant changes in self-perceived risk resulted from the intervention (p is less than .001), and the odds ratio for a change in self-perceived risk when the knowledge score increased by 10% was 1.225. The Centro San Bonifacio HIV Prevention Program successfully reached a Latino community, increased HIV knowledge, and changed self-perceptions of HIV risk.