A solid understanding of the structure and function of cells can help establish the foundation for learning advanced concepts in the biological sciences. The concept of the cell is introduced in middle school life science courses and is continued at the undergraduate level in college (NRC 2012; Reece et al. 2014). Cells are introduced to students as resembling blobs or cubes. Although these descriptions apply to some cells or to cell cultures, more than these shapes exist in nature. The three activities described presented in this article extend a unit that investigates the perimeter-area relationship of cells using tiles (Learning Resources 2006). Investigating the surface-area-to-volume ratio can be done using snap cubes. Each activity can be completed in a class period, activity 1 and 2 in mathematics class and activity 3 in science class.