This study examined the contributions of acculturation, problem-solving appraisal, and career decision-making self-efficacy on 105 Mexican American high school students' educational goals. A standard regression analysis indicated that Anglo-oriented acculturation and problem-solving appraisal accounted for significant variance in educational goals. Mexican-oriented acculturation and career decision-making self-efficacy did not contribute significant variance to students' educational goals. The regression model accounted for 19.5% of the variance in educational goals. Results of the structure coefficients for the predictor variables indicated that Anglo-oriented acculturation and career decision-making self-efficacy were the 2 most important predictors, followed by problem-solving appraisal and Mexican-oriented acculturation, respectively. Implications of the findings are discussed, and recommendations for interventions are provided for enhancing the educational and career development among Mexican American adolescents.