New stakeholders and new roles for old stakeholders have emerged with the development of entrepreneurial universities. A new systemic framework is therefore required which includes these various stakeholders and their goals and thus gives a clear picture of the process of entrepreneurship encouragement and business development support (EE&BDS). The authors propose a model for knowledge transfer and company growth in the context of entrepreneurial universities and science parks. This integrative approach to the roles of the different stakeholders, activities, tools, goals and needs facilitates the arrangement and management of the EE&BDS process. The authors describe and assess their EE&BDS model, presenting the case of the Polytechnic University of Valencia (UPV) and the science park linked to it, the Polytechnic City of Innovation (CPI). The analysis identifies the roles of and relationships among the UPV-CPI stakeholders and shows how this integrative approach can enhance the EE&BDS process for the institution. (Contains 6 figures, 4 tables and 6 notes.)