This study was an attempt to investigate the relationships among stressors, contextual variables, self-efficacy and teacher burnout in Iran as an EFL (English as a Foreign Language) context. A battery of questionnaires was administered to 216 English language teachers of private language institutes. Using Amos version 20, structural equation modelling was run to examine the proposed model of the study. The findings showed that contextual variables could directly cause teacher burnout. They could also do so indirectly by giving rise to stressors, which would in turn increase burnout. The results also highlighted the possible direct and indirect role of self-efficacy in reducing teacher burnout. We argue that self-efficacy could function as a mediator or moderator variable which would reduce the negative effects of contextual variables and stressors on teacher burnout. The results of the present study have important implications for various stakeholders in pedagogy.