This study examines strategic decision-making at the college level in relation to seven theoretical frames. Strategic decisions are those made by top executives, have wide-ranging influence throughout the organization, affect the long-term future of the organization, and are connected to the external environment. The seven decision-making frames identified in the research literature are labeled bureaucracy, collegiality, culture, garbage-can, intuition, politics, and rationality. Fifty deans in academic health centers in public research universities were interviewed with a focus on indicators related to the seven frames and the frames' influence on the process of strategic decision-making. Emergent themes related to strategic decision-making patterns and the seven frames are discussed. This study contributes to the understanding of factors involved in college deans' strategic decisions. As more information is gathered about strategic decision-making in public research universities, specifically academic health centers, better practices will emerge to be supported and encouraged. [The dissertation citations contained here are published with the permission of ProQuest LLC. Further reproduction is prohibited without permission. Copies of dissertations may be obtained by Telephone (800) 1-800-521-0600. Web page: http://www.proquest.com/en-US/products/dissertations/individuals.shtml.]