The Common Core State Standards emphasize higher-order thinking, problem solving, and the creation, retention, and application of knowledge. Achieving these standards creates greater cognitive demands on students. Recent research suggests that active play and regular exercise have a positive effect on brain regions associated with executive function, learning, and memory, thus increasing student achievement. Physical activity increases production of neurotransmitters that support learning readiness; oxygen flow, which facilitates healthy brain functioning, and the brain chemical BDNF, which enhances creation of neurons and synapses. The authors share practical pathways to increase the positive effect of physical activity for students of all ages.