This study compares the use of form and function analogy object boxes to more traditional lecture and worksheet instruction during a 10th-grade unit on human body systems. The study was conducted with two classes (N = 32) of mixed ability students at a high-needs rural high school in central New York State. The study used a pretest/posttest design, in which the two classes alternated between conditions for the four systems (skeletal, digestive, immune, nervous). Both conditions involved students in quality instruction addressing the same concepts for the same amount of time. Additionally, all students participated in hands-on labs. The experimental condition presented students with a set of objects analogous in form and function to parts of a human body system. Students matched objects with cards describing body system parts, mapped the analogies on a chart, generated alternative objects that could be used for the analogy, and finally, created new analogies for other body system parts. Students made significantly higher posttest and gain scores on material learned in the experimental condition, with a mean gain score average of 12.4 points out of 25, compared to 6.2 points in the control condition. Cohen's Effect Size was large, 1.36.