This study investigated the development of effective large-group instructional materials which are relevant and meaningful to the general studies biology student. The criterion of student interest guided the selection of birth, birth control, and genetic counseling as topics for developing relevant prototype instructional materials. These materials utilized many types of instructional methods, including audio-tutorial, programmed instruction, film clips, case histories, and the Didactor computer-type teaching instrument. A pilot study of the prototype materials was conducted with six volunteer students. After being introduced into the regular general studies biology format, analysis of student feedback, questionnaire appraisal, and comprehensive testing of over 600 students led to the final revision of instructional strategies. Questionnaire appraisal of the finalized prototype instructional systems indicated that a decisive majority of students reported the instructional systems to be relevant, current, and interesting. Test data analysis indicated that the students achieved beyond the minimum established criteria for the success of the prototype instructional systems. Test data indicated that the selection of instructional strategies were effective means for the attainment of the respective student behavioral objectives. (Author/MH)