Many US college students are reported to engage in risky sexual behaviour. Smartphone applications are a popular way to provide users with information in real time. We explored the potential for mobile technology to be used in promoting the sexual health of college students. Using findings from an online survey among a random sample of 5000 college students (15% response), we examined sexual behaviours and interest in a sexual health application in January 2012. The majority of students were female (73%) and owned a smartphone (74%). Twenty-nine per cent currently used health-related applications on their phone and 67% reported interest in using a free application that could improve/manage their sexual health. Interest in use varied based on gender, race/ethnicity, sexual orientation, having an unintended pregnancy, sexually transmitted infection (STI) testing, smartphone ownership and past application use. The top most useful features for women included a period tracker (46%), birth control reminder (43%) and STI and pregnancy symptom checker (30%). Women were more likely to be interested in using the application compared with men and those engaging in more sexual activity were more likely to be interested as compared with those engaging in less sexual activity. The evaluation of mobile technology to promote healthy sexuality among college students is warranted.