The rapid rate of expansion of the disciplines of biotechnology, genomics, and bioinformatics emphasizes the increased interdependency between computer science and biology, with mathematics serving as the bridge between these disciplines. This paper demonstrates this inter-relationship within the context of a computational model for a biological process. We designed and implemented a lesson plan for an interdisciplinary science course that examines the evolutionary process from biological, mathematical, and computer science perspectives. The observations obtained from this lesson can be used to augment studies in mathematics with emphasis on arithmetic functions, probability, and generating series.