In a fast-paced, technology-driven world, the age-old custom and etiquette of writing a thank-you note may often be forgotten. Educators need to provide students with the opportunity to master this important professional skill. One might assume that undergraduate biology students have mastered the art of crafting a thoughtful and articulate thank-you note by the time they enter college, but this is not always the case. Because thank-you notes are considered an important part of polite business practice and are emphasized throughout the business world, the skill of writing them is taught in undergraduate and graduate business programs. For students going on to medical school, thank you notes figure in two of the Accreditation Council for Graduate Medical Education skills they are expected to master: professionalism as well as interpersonal skills and communication. The University of New Hampshire is a nonresidential, primarily undergraduate institution, and teaching etiquette to biology undergraduates had not been common practice until recently. To remedy this, students in the BSCI 735 Cell Biology course are required to write thank-you notes to all guest speakers who give presentations to their class. This article describes how the students were prepared for and the benefits of the assignment in helping the students transition from an undergraduate to a successful professional.