Self-actualization, which involves the ultimate development of one's abilities regardless of external influences, is the basis for many personality theories. To assess the relationship between biological sex, sex role, and self-actualization, the Bem Sex Role Inventory (BSRI) and the Personal Orientation Inventory (POI) were administered to 129 male and 264 female college students. Subjects were asked to answer the POI for present and future. Results seemed to contradict an androgynous-positive model of fully functioning human responses suggested by Bem (1974) and Maslow (1954). However, there was considerable support for the masculine-positive model especially for present POI scores. There was a linear relationship with POI scores, using Bem's five sex role categories, from masculine (high POI scores) to feminine (low POI scores). In addition, future POI scores were significantly higher than present scores in the androgynous, near feminine, and feminine groups. Finally, females scored higher on the POI than males. Regression analyses of biological sex and BSRI masculine and feminine raw scores on the POI showed support for a masculine-positive, female-positive, feminine-negative model (in that order) for present POI scores and for a female-positive, feminine-negative, masculine-positive model (in that order) for POI future scores. It was concluded that masculine sex role, not androgyny, is related to self-actualization, and that females may be going to college for more self-actualizing reasons than males. (Author/JAC)