The rapid adoption of transgenic crops in the United States, Argentina, and Canada stands in strong contrast to the situation in the European Union (EU), where a de facto moratorium has been in place since 1998. This article reviews recent scientific literature relevant to the problematic introduction of transgenic crops in the EU to assess if there are specific reasons why transgenic crops have a potentially greater adverse impact on sustainable agriculture in the EU context than elsewhere. Sustainable agriculture integrates three main goals: environmental health, economic profitability, and socioeconomic equity. Transgenic crops do not appear a suitable tool for sustainable agriculture in the EU due to specific environmental, economic, and socioeconomic reasons. Therefore, a moratorium on transgenic crops based on the precautionary principle should be officially adopted until proper risk assessment. In addition, agroecological alternatives to transgenic crops fit better the EU vision of agriculture.