A service-learning project appropriate for a biochemistry or advanced biochemistry course was designed and implemented. The project involved students partnering with a homeless shelter to design informational pamphlets to be displayed at the shelter for the clients' use. The pamphlet topics were based on diseases studied within the course. Students were required to present a rough draft of their project to the class for comments and revisions and give a brief presentation. The assignment allowed students to use their knowledge and expertise learned within the course and to apply their education by creatively designing a public-service pamphlet. Integrating service learning into an upper-level biochemistry course improved student communication, writing, and critical-thinking skills. Students reported that the service-learning component of the course increased motivation to learn course content. (Contains 2 tables and 2 figures.)