University environments are fertile grounds for risky sexual behaviors. This study investigated students' risky sexual practices at the University of KwaZulu-Natal in Durban, South Africa. Data were collected using quantitative and qualitative methods. A total of 1,405 questionnaires were administered, and 80 in-depth interviews and four focus group discussions were conducted. Quantitative data were analyzed using the Statistical Package for the Social Sciences (SPSS) for Windows 16.0. Qualitative data were analyzed using thematic analysis. The sample included 1,405 students, the majority (93%) of whom were never married and 97% were sexually experienced. Among males reporting male partnerships those who used alcohol were significantly more likely to report risky sexual practices. Among females reporting male partnerships, those 30 years and older were significantly less likely to report engaging in risky sexual behavior with male partners. Alcohol use was connected with inconsistent condom use and not using condom last sex among females. While low rates of condom use were a problem among older students aged 30 years and older, and risky sexual practices were more common among younger students. Risky sexual behaviors pose a big challenge for the successful HIV prevention interventions on university campuses.