Native American Nations have perpetually had the highest rates of poverty and unemployment and the lowest per capita income of any ethnic population in the United States. Additionally, American Indian students have the highest high school dropout rates and lowest academic performance rates as well as the lowest college admission and retention rates in the nation. As Native Nations try to reverse these trends through sustainable economic development, they must do so with a limited number of educated, skilled workers in their own communities and with a complicated relationship with higher education that obstructs their ability to create a viable work force. This qualitative study proposed to research American Indian postsecondary access within the context of Native nations' sovereignty and their social and economic development. Utilizing a theoretical framework of human capital and its role in rebuilding Native American economies, interviews were conducted with 19 education informants representing federally-recognized tribes in the Southern Plains Region. Major themes included financial issues related to college going in Native populations, familial and community influences, academic readiness, curricular development and delivery, the role of higher education in preparing students for tribal employment, and tribal economic development. Increasing Native American college student success and preparation for tribal employment requires collaboration between the sovereign nations and postsecondary entities that serve their populations. Ultimately, tribes will benefit from developing, or continuing to develop, a culture of college going in their communities, educational institution partnerships that create support services for their students, and curriculum to support the training of future tribal leaders. This study reinforces the importance of human capital in economic development for tribes and highlights the critical role that higher education can play in preparing American Indian students to serve their tribes. [The dissertation citations contained here are published with the permission of ProQuest LLC. Further reproduction is prohibited without permission. Copies of dissertations may be obtained by Telephone (800) 1-800-521-0600. Web page: http://www.proquest.com/en-US/products/dissertations/individuals.shtml.]