This article presents a transcribed audio recording of the invited address the author gave to Sigrid Glenn on the relations between cultural materialism and radical behaviorism at the 12th annual conference of the Association for Behavior Analysis in Milwaukee, Wisconsin on May 23rd, 1986. In his address, the author emphasizes that the necessity for dealing with the classes of individual responses and sociocultural systems as a level of phenomena with a distinct set of selection processes and lawful regularities arises not from any special emergent essences peculiar to human cultural life, such as mind, will, intention, consciousness, symbolic thought, or even verbal behavior, as the majority of his anthropological colleagues contend, but rather from the quantitative enormity of the numbers of individuals and responses that underwrite that abstraction and classification of sociocultural components and all systems. He points out that cultural materialism and radical behaviorism are natural allies, and that both strategies rest upon a common epistemological foundation.