Despite Asperger's Syndrome (AS) becoming a widely recognized disorder on the pervasive developmental spectrum, surprisingly few studies have assessed the utility of psychosocial and/or pharmacological treatments for children with AS. Further, studies have not examined the effects of treatment on disruptive behavior problems commonly exhibited by children with AS. This case study demonstrates the positive effects of an intensive, long-term, multimodal treatment targeting the symptoms and functional impairment of a school-age male with AS and comorbid disruptive behavior problems. Components of the comprehensive treatment included a behavioral summer treatment program, behavioral parent and teacher training, and medication. Results highlight the potential efficacy of treating the chronic functional impairments of AS and associated behavior problems with an intensive, long-term, multimodal treatment.