The number of children classified with autism in US schools has risen sharply over the past decade. School psychologists are being called upon with increasing frequency to assist in the identification, assessment, and treatment of these children. The diagnostic complexities and heterogeneity of the disorder make dealing effectively with this condition a considerable challenge for school personnel. Additionally, the biological basis of the disorder necessitates the involvement of medical personnel in both assessment and intervention. This article reviews recent findings regarding the genetics of autism, associated neurological features, best practice assessment, and empirically supported interventions.