The reach of art therapy in assisting a hospice patient in confronting existential issues at the end of life is illustrated in this article with a case that took place over the course of 22 semiweekly sessions. Painting with an art therapist allowed the patient to shift from a state of anxiety and existential dread to a more accepting, fluid awareness of the dying process. Additional benefits to the patient included improved quality of life, self-expression, and meaning making, as well as an increased ability to relate to the art therapist and to connect with family members and staff. The case illustrates the power of art, art therapy, and the therapeutic relationship in coping with end-of-life issues and concerns.