The purpose of the study is to contribute to the understanding of quality of life as it is experienced by a community-based, nonclinical sample of individuals with HIV/AIDS by applying family resiliency theory and cognitive appraisal concepts of uncertainty and optimism. Through the use of a Web-based survey, 125 individuals with HIV/AIDS completed an online questionnaire. Disease progression, as measured by CD4 count, is not found to be related to quality of life. When considered separately, both the family resiliency variables and the cognitive appraisal variables are found to predict quality of life. The overall prediction model, composed of the three sets of predictor variables--cognitive appraisal, family resiliency, and disease progression--is found to explain over 60% of the variance in quality of life of people with HIV/AIDS. (Contains 3 tables.)