Using multiple theoretical perspectives (stress, conservation of resources, and deviance), we investigated the relationship between burnout and personality. Burnout is measured with the Maslach Burnout Inventory (emotional exhaustion, depersonalization, and personal accomplishments), and personality is captured with the Mini-Marker Inventory (extroversion, conscientiousness, agreeableness, openness to experience, and emotional stability). Regression analyses controlling for demographic characteristics, based on 265 instructors of a large state university, indicated that emotional exhaustion is negatively related to extroversion and emotional stability and positively related to openness to experience. Depersonalization is negatively related to agreeableness and emotional stability. Personal accomplishments are positively related to extroversion, conscientiousness, agreeableness, and emotional stability. Implications of the results are discussed. (Contains 6 tables and 4 notes.)