This study concerns the effect of letter position on the retention of words by EFL learners. Given the fact that everyone has a mental lexicon, we would suggest that words are possibly organized in alphabetical order, then it would be likely for the learners to retain the words easily when exposed to the first letters of given words. The study attempts to find whether the letter position enhances word retention. Three different positions of letters were selected: first, middle, and final letters. The chosen words have the same number of syllables and stress pattern. Running repeated measures ANOVA, as the appropriate statistical analysis, The 212 subjects of this study demonstrated much better retention when exposed to the first letter in comparison with the middle and final letters. The finding can be used in the classroom to help students recall the words that they already knew.