The authors show associations between immigration and alcohol disorders using data from the 1995 and 2000 U.S. National Alcohol Surveys and the 1998 Mexico National Household Survey on Addictions. The prevalence of alcohol dependence was 4.8% for the Mexicans, 4.2% for the Mexico-born immigrants, and 6.6% for the U.S.-born Mexican Americans. They found a general lack of significance for the immigration variables with few consistent dose-response findings for alcohol use disorders. High acculturation was associated with higher risks for women; however, unexpectedly, high acculturation was associated with lower risks for males. Among Mexican Americans, the impact of immigration to the United States on the prevalence of alcohol use disorders differs by gender. Male and female differences and possible sources of immigrant selection are important issues for future research. (Contains 4 tables.)