Recent efforts in engineering education focus on introducing engineering into secondary math and science courses to improve science, technology, engineering, and math (STEM) education (NAS, 2010). Infusing engineering into secondary classrooms can increase awareness of and interest in STEM careers, help students see the relevance of science and math in their everyday lives, and increase STEM literacy. This paper describes how the knowledge integration framework provides research-based guidelines to help secondary students develop and connect science and engineering concepts. Results from technology enhanced curriculum units demonstrate how instruction based on knowledge integration principles and patterns using the Web based Inquiry Science Environment (WISE) can infuse engineering into existing secondary science classrooms. This paper explores how the knowledge integration framework can guide curriculum development and assessment of engineering concepts and habits of mind.