The purpose of this article is to describe several conceptual areas that warrant attention by scholars and practitioners interested in improving access and opportunity to science, technology, engineering, and mathematics (STEM) learning in urban cities. Thinking conceptually about the urban context has been a part of intellectual traditions in the social sciences for decades. Like in other fields of study, for example, economics, sociology, and political science, the treatment of urban communities as unique geospatial organizations in terms of sites of intervention and policy reform has a history in STEM education, but the aligned research and development strategy is best characterized as nascent. (Contains 9 notes, 1 figure and 1 table.)