Purpose: To examine tobacco farmers' attitudes toward tobacco control, public health, and tobacco manufacturers in order to determine the extent to which rapidly changing economic conditions have influenced North Carolina tobacco farmer attitudes in ways that may provide tobacco control advocates with new opportunities to promote tobacco control policies in tobacco-dependent US communities. Methods: We used data from a longitudinal sample of North Carolina tobacco farmers across 5 waves of data collection (1997-2005) (baseline N = 749 farmers). Generalized linear mixed models were used to examine changes in attitudes toward tobacco control and tobacco manufacturers, controlling for economic dependence on tobacco, and demographic factors. Results: Over the study period there was reduction in tobacco farmers' perceptions of threat from tobacco control initiatives. Conclusions: These changes in attitude may signal an opportunity for successful tobacco control activity in traditionally tobacco-dependent states and rural communities.