In this article the authors present a review of literature from multiple disciplines pertaining to using eBooks in the classroom in order to understand the underlying literacy and technology related issues and challenges. eBooks brought about changes in how students learn to read, and in how they read to learn. They require students to learn new literacies and to use new technologies, which has had a profound impact on reading pedagogy in K-12 classrooms. Dedicated eBook readers, smartphones, and tablet computers have led to changes in a signature pedagogy--reading literacy instruction. Research is needed on how to best teach the new literacies to help learners adapt to the challenges of new media and technologies.