Objective: This analysis examined the effectiveness of utilizing interferon-gamma release assay (IGRA) technology in a TB (TB) screening program at a university. Participants: Participants were 2299 students at a Montana university who had presented to the university health center for TB screening during 2012 and 2013. Methods: A retrospective study was conducted utilizing data from student health center medical records. Time and financial expenditures were determined, and the cost of the present screening process and 2 alternative scenarios was calculated. Results: The current process is the most costly and time-consuming scenario for TB testing. Testing exclusively with IGRAs is the least labor-intensive for staff and creates revenue, whereas a dual method, utilizing IGRAs for high-risk students and skin tests for others, provides a solution that better responds to the demographic of the population. Conclusions: This assessment shows that IGRAs are a cost-effective tool for screening a global student population.