ERIC Number: EJ744270
Record Type: Journal
Publication Date: 2006
Pages: 6
Abstractor: Author
ISBN: N/A
ISSN: ISSN-0891-4222
EISSN: N/A
The Effect of Acetyl-L-Carnitine Administration on Persons with Down Syndrome
Pueschel, Siegfried M.
Research in Developmental Disabilities: A Multidisciplinary Journal, v27 n6 p599-604 Nov-Dec 2006
Since previous investigations reported improvements in cognition of patients with dementia after acetyl-L-carnitine therapy and since there is an increased risk for persons with Down syndrome to develop Alzheimer disease, this study was designed to investigate the effect of acetyl-L-carnitine administration on neurological, intellectual, and social functions in adults with Down syndrome. In this double-blind study we enrolled 40 individuals with Down syndrome and administered acetyl-L-carnitine to the study group during a six months period. Specified examinations and psychological tests were given to persons in both the study and control groups at the start of the investigation and at 3, 6, and 9 months. A detailed analysis of the data revealed that acetyl-L-carnitine administration did not enhance central nervous system functions and that it did not benefit persons with Down syndrome.
Descriptors: Down Syndrome, Alzheimers Disease, Adults, Psychological Testing, Patients, Dementia, At Risk Persons, Outcomes of Treatment, Molecular Biology, Cognitive Ability, Interpersonal Competence, Psychological Patterns, Neurological Impairments, Comparative Analysis
Elsevier. 6277 Sea Harbor Drive, Orlando, FL 32887-4800. Tel: 877-839-7126; Tel: 407-345-4020; Fax: 407-363-1354; e-mail: usjcs@elsevier.com; Web site: http://www.elsevier.com.
Publication Type: Journal Articles; Reports - Research
Education Level: N/A
Audience: N/A
Language: English
Sponsor: N/A
Authoring Institution: N/A
Grant or Contract Numbers: N/A