Cyberinfrastructure is the IT infrastructure that enables scientific inquiry. It anticipates a scientific and scholarly world that is increasingly dependent on information technology. It has many facets, and each institution will need to review its own strengths and weaknesses to decide on areas of concentration. In higher education, cyberinfrastructure is required for conducting research, obtaining a competitive edge, participating in national and global projects, and addressing important trends. In this article, the authors give a few ideas to consider in one's approach to cyberinfrastructure. The goal is to help one compose a five-minute conversation on cyberinfrastructure appropriate for various audiences. This article builds on the work of the Campus CyberInfrastructure (CCI) Working Group sponsored by EDUCAUSE. (Contains 2 endnotes.)