Despite the general effectiveness of multimedia instruction, students do not always benefit from it. This study examined whether students' learning from multimedia can be improved by teaching them relevant learning strategies. On the basis of current theories and research on multimedia learning, the authors developed a strategy training for 9th-grade students. To evaluate it, 31 students received the aforementioned training and 33 students received placebo control training. After that, students completed a multimedia learning session on meiosis. Results showed that although the experimental training improved students' strategy knowledge, it had no effect on learning outcomes. Accordingly, students acquired strategy knowledge but did not apply it later. Implications for the design of multimedia strategy interventions and future research are discussed.