The purpose of this study was to investigate the effect of case studies on Primary School Teaching students' attitudes toward chemistry lesson. The study was conducted on 63 freshmen from Department of Primary School Teaching at a university in Turkey. The students were taught using case studies about the subjects of Properties and States of Matter, Elements and Compounds, Solutions and Mixtures, Physical and Chemical Changes, Chemical Reactions, Acids and Bases, Solubility and Precipitation. In the study, one group pre-test and post-test experimental design was used. As the tool of supplying data, Attitude toward Chemistry Lesson Scale was applied to determine students' pre and post attitudes. The results of analyzing the scale showed that chemistry education based on case studies caused significantly positive attitudes toward chemistry lesson. (Contains 2 tables.)