This study examined the relationships among peer-to-peer sexual harassment, school climate, adult-to-student harassment, and outcomes (psychological and physical well-being; school withdrawal and safety) for high school girls (n = 310) and boys (n = 259) recruited from seven public high schools in a Midwestern state. More frequent, severe peer harassment was associated with being female; holding climate perceptions that one's school is tolerant of the harassment of girls; and experiencing more frequent, severe harassment by school personnel. The correlates associated with outcomes varied by outcome, with climate exerting a consistent influence on boys' outcomes. Girls' outcomes were associated with climate, harassment, or both. Findings suggest that more frequent, severe experiences of sexual harassment in the schools are associated with direct, negative effects on girls and indirect, negative effects on boys and girls through a school climate that tolerates the harassment of girls.