Single-subject research (SSR) is an experimental research tradition that is well established in other fields (e.g., special education, behavior analysis) but has rarely been applied to topics in gifted education. In this Methodological Brief, Brandi Simonsen and Catherine A. Little from the University of Connecticut highlight the key features of SSR, describe typical SSR designs, and present examples to illustrate how each design could be applied to topics in gifted education. (Contains 1 figure.)